There’s nothing quite like a toothache that seems to get worse the moment your head hits the pillow. If you’ve ever found yourself wondering, “What should I do if I have a toothache?”—especially in the middle of the night—you’re not alone. While a nighttime toothache often signals an issue that needs professional care, there are a few simple ways to manage discomfort and get some much-needed rest until you can see your dentist.